SAB and DoD advance therapeutic drug candidate for Covid-19

17 April 2020 (Last Updated April 17th, 2020 15:30)

SAB Biotherapeutics (SAB) has won an expanded scope from the US Department of Defense (DoD) on its Rapid Response contract for its new therapeutic drug candidate, SAB-185, to treat coronavirus (Covid-19) pandemic.

SAB and DoD advance therapeutic drug candidate for Covid-19
SAB Biotherapeutics has won an expanded scope on its Rapid Response contract for its new therapeutic drug candidate to treat Covid-19 pandemic. Credit: SAB Biotherapeutics.

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SAB Biotherapeutics (SAB) has won an expanded scope from the US Department of Defense (DoD) on its Rapid Response contract for its new therapeutic drug candidate, SAB-185, to treat coronavirus (Covid-19) pandemic.

The contract has been awarded by the US Department of Defense (DoD) Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (JPEO – CBRND) and Joint Project Lead for Enabling Biotechnologies (JPL-EB).

The $9.4m contract is supported by the Biomedical Advanced Research Development Authority (BARDA).

BARDA is part of the Assistant Secretary for Preparedness and Response (ASPR) at the US Department of Health and Human Services.

The therapeutic candidate generates targeted human antibodies without the need for human donors.

The initial lot of SAB-185 therapeutic candidate is expected to be available for clinical evaluation this year.

Generated using DiversitAb platform, the immunotherapy produces fully human polyclonal antibodies targeting the SARS-CoV-2 virus that causes Covid-19.

Once enabled, the approach is expected to produce greater quantities of neutralising antibody product.

The development will simultaneously overcome other challenges of traditional human antibody donor methods including the need to identify, screen, and draw blood from recovering volunteers.

The scope of current JPL-EB rapid response contract has been expanded and funded by the DoD. This has been categorised as ‘Stage 4: Covid-19 Pandemic Response.’

SAB Biotherapeutics president, CEO and co-founder Eddie Sullivan said: “SAB has developed a unique system to naturally, rapidly, and consistently produce large amounts of targeted human antibodies without human donors, as we have done with MERS and Ebola.

“Our targeted high-potency immunotherapies leverage the native immune response thereby providing a highly specific match against the complexity, diversity and mutation of a disease.

“We have data in other indications demonstrating that our therapies are much more potent than those produced from convalescent plasma from recovered patients and data showing SAB’s therapies remain effective when other therapeutics may develop resistance.”