US Army General David Perkins has reportedly said that a Patriot long-range air defence system was used by an American ally to shoot down a small quadcopter drone.
The Raytheon-built missile system has been designed to counter tactical ballistic missiles, cruise missiles and advanced aircraft.
Speaking at the Association of the US Army's Global Force symposium in Alabama, Perkins was quoted by BBC as saying: "That quadcopter that cost 200 bucks from Amazon.com did not stand a chance against a Patriot.
"Now, that worked, they got it, OK, and we love Patriot missiles.”
The details about when and where the strike was carried out were not revealed.
Commenting on the strike, Royal United Services Institute researcher Justin Bronk was quoted by the news agency as saying: "It is clearly enormous overkill.
"It certainly exposes in very stark terms the challenge which militaries face in attempting to deal with the adaptation of cheap and readily available civilian technology with extremely expensive, high-end hardware designed for state-on-state warfare."
The Patriot was recently upgraded with GaN-based AESA radar technology to increase its detection range and power, as well as enable 360° coverage.
The upgrades also allow the system to fire multiple missile types to destroy a range of threats.
To date, Patriot has been tested more than 2,500 times with the US Army under real-world conditions, according to Raytheon.